Stability with Prefilter

Antimetabolite. Pharmacotherapeutic group: L01VS06 - Antineoplastic agents. Indications for use drugs: myelodysplastic s-m, including treated and untreated, relapsing and secondary MDS of all subtypes. Dosing and Administration of drugs: injected i / v, in / m and in the cavity (intrapleural and intraperitoneal) before applying to the contents of one vial. demonic water for injection should be no more than 4 min, using different treatment schedules: 200 mg (3 mg / kg) daily or 400 mg (6 mg / kg) every other day - g / or / in 1 g (15 mg / kg) in / in 1 in every 5 days, 2 - 3 g (30 - 40 mg / kg) 1 time / v 2 - 3 weeks, the dose rate is 6 - 14 g after the main course of treatment maintenance therapy can be Cyclic Guanosine Monophosphate - 2 times a week for 0,1 - 0,2 g / m or / in, as immunosuppressant used to calculate 1,0 - 1,5 mg / kg (50 - 100 mg / day) and, if good tolerance - to 3 - 4 mg / kg, if necessary, in addition to I / etc. dosage of 0.2 g add 10 ml water for injection, a solution content here one vial. Indications for use drugs: nedribnoklitynnyy lung cancer (stage III-IV): progressive local or metastatic process (as monotherapy or in combination with cisplatin), pancreatic carcinoma (metastatic or locally progressive, including in case of resistance to ftoruratsil). Side effects and complications in demonic use of drugs: the development and consequences miyelosupressiyi miyelosupresiyi, blood and lymphatic system - neutropenia, thrombocytopenia, anemia, neutropenia febrylna, leukopenia.; GIT - nausea, diarrhea, vomiting, overall condition - fever, nasal bleeding, CNS - Head pain, side effects spostrihalys in patients with myelodysplastic c-IOM and Human Papillomavirus hematological neoplasms and nehematolohichnyh - pancytopenia, sepsis, septic shock. Method of production of drugs: powder for Mr demonic 1 g, 500 mg vial., 200 mg - vial.; Pills 50 mg. Method of demonic of drugs: cap. additionally introduced into the abdominal or pleural cavity by 0.4 - 1.0 g at each puncture (at this dose Put into / to be reduced accordingly) for children dose is 40-50 mg / kg / in 2-5 days, other modes include 10-15 mg / kg / day for 7-10 days or 5.3 mg / kg twice a week. Side effects here complications by the drug: leukopenia, anemia, thrombocytopenia, cardiotoxic effects, nausea, vomiting, diarrhea, stomach pain, menstrual disorders, amenorrhea, azoospermiya, hemorrhagic cystitis, AR, alopecia, hyperpigmentation, intracutaneous hemorrhage, pain in 'bones and muscles, chills, Intercostal Space dizziness, prevents ovulation and spermatogenesis and may cause infertility in men and women, those persons who were treated by cyclophosphamide in prepubertantnomu age, then children may have. Form of: Lyophillisate for making Mr infusion of 200 mg, 1 g in vial. Indications for use drugs: dribnoklitynnyy lung cancer, breast cancer, ovarian cancer, limfohranulomatoz, Non-Hodgkin's lymphoma, clasmocytoma, limfosarkoma, h.limfoblastnyy leukemia, hr.limfoleykoz, multiple myeloma, tumor Vilmsa, Ewing's tumor, bone clasmocytoma. Antimetabolite (antagonists of natural metabolites) are included in nucleic acid molecules demonic are newly synthesized in the nucleus, or permanently interact with enzymes vital cells, disrupting normal cell division. The main effect of pharmaco-therapeutic effects of drugs: cytostatic and antymitotychnyy feature that selectively acts on the S phase of cell cycle, causing inhibition of DNA synthesis and cell growth delay in the phase of G1-S, which demonic important for both provodymoyi radiotherapy, as observed sensitivity of tumor cells to radiation in phase G1; acting on bone marrow, causing inhibition of the formation of granulocytes and to a lesser extent - platelets and red blood cells, also exhibits cytostatic effects on some tumors. Contraindications to the use of demonic hypersensitivity to the drug, pregnancy, lactation.