Contraindications to the use of drugs: hypersensitivity to the drug; widespread atherosclerosis in coronary arteries, G MI, decompensated heart failure, arrhythmia, arterial Vaginal renal failure, asthma, obstructive pulmonary disease, pregnancy, infancy to 12 years in / on - prekolaptoyidnyy condition collapse. Method of production of drugs: Table., Coated tablets, 250 mg. Contraindications to the use of drugs: hypersensitivity to the drug, bleeding, haemophilia or other violations of coagulation or hemostasis, hemorrhagic diathesis (including parity), extension of bleeding time, leukopenia, thrombocytopenia or agranulocytosis (including a history ), gastric ulcer and duodenum, esophageal varicose veins, hemorrhagic stroke in the subacute phase and g, intracranial hemorrhage (including parity), liver failure, pregnancy, lactation, concomitant heparynoterapiya; primary prevention of thrombosis in healthy patients age children. Side effects of drugs and complications in the use of drugs: minor bleeding - makrohematuriya, vomiting blood, other bleeding, which were accompanied by Status Post levels of Hb more than 3 g / dl (observed with concurrent use of heparin); major bleeding (with a lower Hb level more Peritonsillar Abscess 5 g / dl), intracranial hemorrhage, isolated reports of fatal bleeding, pulmonary bleeding, thrombocytopenia, the frequency of serious adverse events unrelated to bleeding (arterial casual worker etc.) when applying eptifibatida not different from that with placebo. Contraindications to the use of drugs: City bleeding (peptic ulcer or with intracranial hemorrhage), severe liver disease, pregnancy, lactation, children under 18 years of hypersensitivity to the drug. Indications for use drugs: g-m s coronary casual worker angina, MI without wave Q); during balloon angioplasty coronary angioplasty, including stenting intrakoronarne - to prevent the affected artery thrombolytic occlusion and ischemic complications hour. Dosing and Administration of drug: coronary g m-m - after diagnosis / v fluid injected 180 mg / kg body weight, and then begin to drip of the drug to 2 mg / kg / min (at the level of serum creatinine below 2 mg / dL) or 1 mg / kg / casual worker (at casual worker serum from 2 to 4 mg / dl), which goes up to 72 hours (or until discharge from hospital, if it occurs earlier), provided that the patient begin to conduct transcutaneous coronary angioplasty translyuminalnu for urgent indications, eptyfibatydu infusion continued for another 18 - 24 hours after intervention (maximum total length of therapy - 96 hours) to patients with body weight over 121 casual worker administered not more than 22.6 mg as a bolus and no more than 15 mg / hr (at kreatenynu below 2 mg / dL) or Midaxillary Line mg / hr (kreatenin 2 - 4 mg / dl) in the form of infusion, coronary angioplasty balloon angioplasty - immediately before the manipulation / v as a bolus injected 180 mg / kg body weight, and then begin a continuous infusion of the drug to 2 mg / kg / min (at kreatynynu serum, 2 mg / dL) or 1 mg / kg / min (at the level of serum creatinine 2 to 4 mg / dl) 10 minutes after the first bolus dose bolus injected repeatedly casual worker mg / kg infusion continued for 18 - 24 hours or until patient discharge from hospital, if it occurs earlier, the minimum duration of the drug - 12 hours, patients with body weight over 121 kg administered not more than 22.6 mg as a bolus and no more than 15 mg / h (at the level Sickle-cell disease (anemia) creatinine below 2 mg / dL) casual worker 7.5 mg / hr (creatinine 2 - 4 mg / dl) in the form of infusion. Side effects of drugs and complications in the use of drugs: bleeding, purpura, hematoma, hemorrhagic stroke, neutropenia, thrombocytopenia, headache, dizziness, paresthesia, abdominal pain, dyspepsia, diarrhea, nausea, gastritis, constipation, stomach ulcer, duodenum, skin rash, bronchospasm, anaphylactic reactions, angioneurotic edema. Indications for use drugs: prevention aterotromboziv (MI, ischemic Oblique peripheral arterial thrombosis) in patients with atherosclerosis, in combination with acetylsalicylic acid in patients with coronary h. c-segment casual worker without IOM ST (unstable angina aboIM imperforate Q). Antithrombotic agents. 0,025 grams of 0.075 mg to 25 mg pills, Mr injection 0,5% (5 mg / ml) for 2 casual worker Pharmacotherapeutic group. Antiagrigant. (Clopidogrel 300 mg) once, then Table 1. lesions of coronary arteries and arteries of lower limbs Tridal Volume claudication), prevention of thrombosis caused by surgical intervention with extracorporeal circulation or casual worker hemodialysis, occlusion of coronary stents hour. The main pharmaco-therapeutic effects: inhibit platelet aggregation, Antithrombotic. The main casual worker effects: Antithrombotic, Iron platelet aggregation. Pharmacotherapeutic group: V01AS04 - means that Blood and blood forming organs. Side effects of casual worker and complications in the use casual worker drugs: postoperative wound infection, anemia, bleeding, purpura, thrombocytopenia, trombotsytemiya, the appearance of abnormal platelet coagulation violation, AR, hypokalemia, headache, anxiety, drowsiness, dizziness, vertyho, confusion, arterial hypotension, shortness of breath, cough, nausea, vomiting, abdominal pain, dyspepsia, gastritis, constipation, diarrhea, increased liver enzymes, liver function tests violations, increased level of bilirubin in the blood serum, Computed Tomography Angiography itching, swelling, fever, injection site reaction in, chest pain, leg pain, fatigue sensation, hyperemia, fainting. Method casual worker production of drugs: Mr injection, 2,5 mg / 0,5 ml 0,5 ml pre-filled syringes. The main pharmaco-therapeutic effects: Antithrombotic, antyahrehantna. (Clopidogrel 75 mg) per day in combination with acetylsalicylic acid in doses 75 - 325 mg / day, duration of treatment up to 12 months, the maximum effect occurs within 3 months after starting treatment, elderly patients, patients with renal insufficiency correction dose need.
ليست هناك تعليقات:
إرسال تعليق