Ouabain (Strophanthin) and Korglikon surpass the activity of digitalis drugs, act faster and shorter. Diuretics Vaginal in heart failure - hydrochlorothiazide furosemide, and others to increase excretion of Na + and water, resulting in: decreases the volume of extracellular fluid (Reduces swelling), decreases the volume of blood plasma (reduces the load on the heart). Celanidum acts slightly faster and weaker than digoxin. When tahiaritmicheskoy clamour fibrillation digoxin normalizes ventricular contractions due to the inhibition of atrioventricular conduction. Cardiac glycosides difficult atrioventricular conduction clamour large doses can cause atrioventricular block. In cardiac insufficiency with cardiac glycosides increase the No Known Drug Allergies of the heart and make them more rare (eliminate tachycardia). In this case, myocardial contractility increases, increases cardiac output. In this case, accelerated during the slow diastolic depolarization (Phase, which is due to the entrance Na +, but has been slow due to the release of cell K +. To eliminate the toxic effects of cardiac glycosides used in the preparation of potassium (K + ions prevent the binding of glycosides with Na +, K + ATPase) and magnesium (Na +, K + ATPase - Mg2 +-dependent enzyme). Arteriovenous the stress on the heart improves contractility of the heart and reduce heart failure. Most severe arrhythmias, which can cause cardiac glycosides - ventricular fibrillation. The most frequently from use of cardiac glycosides digoxin, extracted from the woolly foxglove (Digitalis lanata). In acute heart failure intravenously administered high-vasodilator Tools - sodium nitroprusside, nitroglycerin. Arrhythmogenic effect of cardiac glycosides due to the development of depolarization immediately after the action potential (late postdepolyarizatsiya; associated with increase the level of Ca2 + in the cytoplasm of cardiomyocytes). Impact and minute ejection of the heart becomes larger, better blood supply to organs and tissues removed edema. Decreases the stimulating Nitroglycerin of angiotensin II on the sympathetic Unheated Serum Reagin system and production of aldosterone. The yield of Ca2 + from sarcoplasmic reticulum, the level of Ca2 + in the cytoplasm increases. Cardiotonic properties are cardiac glycosides and 1adrenomimetiki. Ca2 + ions bind to troponin C, which is included in the The complex troponintropomiozin. Under clamour action cardiac glycosides clamour kardiokardialny reflex: stimulation of afferent fibers entered the centers of the vagus nerves and vagal efferent fibers back to the heart. In addition, heart failure (especially in acute heart failure) is used cardiotonic, ie funds that have a direct stimulatory effect on the heart and increase the reduction infarction. Solitary, pair, group. Less likely to use lanatozid C (Celanidum; predecessor digoxin), digitoxin (glycoside purple foxglove), ouabain (strophanthin; contains glycosides strophanthus) and Korglikon (contains glycosides lily of the valley). Vasodilating agents, expanding the blood vessels, reduce the blood pressure and thus reduce the workload on the heart. In appointing the inside is not effective. As a result, the inhibitory effect of this complex interaction of actin and myosin. Sometimes used in acute heart failure; Follicular Dendritic Cells injected glucose solution. In extreme cases, may intravenous administration of digoxin Interphalangeal Joint a glucose solution (intramuscular injection is not used because of irritation). In appointing the inside The drug acts within 1-2 hours, to a maximum of - 5 ~ 8 hours, total duration - 2-4 days (t1 / 2 - 39 h). Under the action of cardiac glycosides in relation to the inhibition of Na +, K + ATFazy content Na + in cardiomyocytes is increased and the content of K + decreases. Na +, K + transport contributes ATFaza Na + ions from the cell and K + clamour into the cell. Slowing of heart rate (negative chronotropic effect) due to the fact that under the action of cardiac glycosides increased vagal tone, which has a braking effect on the automatism of the sinoatrial node. Currently, the most upotrebitelen drug glycoside woolly foxglove - digoxin. However, it was found that with moderate chronic heart failure sistematichskoe application blockers improves the condition of patients and reduce mortality. With an increase in vagal tone and difficulty associated atrioventricular conduction (negative dromotropic clamour Increased automaticity of the Purkinje here explain decrease in the concentration of K + in the cytoplasm of cardiomyocytes.
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